Distinct involvement of NF-κB regulators by somatic mutation in ocular adnexal malt lymphoma
نویسندگان
چکیده
منابع مشابه
A20 inactivation in ocular adnexal MALT lymphoma.
Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma. However, the incidences of A20 abnormalities and their clinical impact remain for the most part unknown. It is also unknown whether ABIN-1 and ABIN-2, the components of the A20 NF-κB inhibitor complex, are inactivated by genetic changes in ocular ad...
متن کاملMutation analysis of NF-κB signal pathway-related genes in ocular MALT lymphoma.
Constitutive nuclear factor-kappa B (NF-κB) activation has been reported in ocular adnexal lymphoma (OAL). TNFAIP3/A20 is a "global" inhibitor of NF-κB pathway. We have shown that OAL has preferential loss of the 6q23.3 region where TNFAIP3/A20 exist, which is suggested to involve in lymphomagenesis of OAL. The mechanisms causing NF-κB activity in OAL remain elusive. Recently, NF-κB canonical p...
متن کاملRecurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas
The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is still poorly understood. We analyzed 63 cases of such lymphomas for non-synonymous mutations in 24 candidate genes by amplicon sequencing. We validated frequent mutations in the NF-κB regulators MYD88, TNFAIP3 and TNIP1 in OAML, but also identified recurrent mutations in several addit...
متن کاملChlamydia-psittaci-eradicating antibiotic therapy in patients with advanced-stage ocular adnexal MALT lymphoma.
Twenty-five percent of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma (OAML) patients have disseminated disease (distant nodal and/or extranodal lesions) [1]. These patients are usually treated with chemotherapy, which is active though, sometimes, too toxic, or with rituximab, which is better tolerated but has only transient activity. Generally, these patients experience multi...
متن کاملBacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial.
BACKGROUND An association between ocular adnexal MALT lymphoma (OAL) and Chlamydia psittaci (Cp) infection has been proposed, and recent reports suggest that doxycycline treatment causes tumor regression in patients with Cp-related OAL. The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested. METHODS In a prospective trial, 27 OAL patients (15 newly diagnosed and 12 ...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2012
ISSN: 0007-1048
DOI: 10.1111/bjh.12162